Retail outlet at place temperature clear of dampness and warmth. Usually do not freeze. Keep track of your drugs. You need to be aware if anybody is making use of it improperly or without a prescription.
Promethazine is very well absorbed in the gastrointestinal tract. Scientific outcomes are apparent within 20 minutes immediately after oral administration and customarily previous 4 to six hrs, although they may persist assuming that 12 hrs.
The vast majority of scientific tests, equally favourable and unfavorable, have been confined by small sample sizing, remember bias and absence of knowledge with regards to dose and timing of publicity.
There's a connection concerning increasing codeine plasma focus and increasing frequency of dose-linked opioid adverse reactions for example nausea, vomiting, CNS effects, and respiratory despair.
Hold a summary of all the products you use (including prescription/nonprescription medicines and herbal products) and share it with your health care provider and pharmacist. Never start off, cease, or alter the dosage of any medicines without your medical doctor's acceptance.
This is simply not a whole list of feasible Unintended effects. Should you detect other Unwanted side effects not shown earlier mentioned, Speak to your medical doctor or pharmacist.
No evidence of tumorigenicity was observed in male and woman mice at codeine dietary doses up to four hundred mg/kg/working day (close to comparable to 45 times the MRHD with a mg/m2 foundation).
Keep in mind that this medication continues to be prescribed mainly because your doctor has judged that the reward to you personally is greater than the risk of Unwanted side effects. A lot of people using this medication don't have critical Unwanted side effects.
Promethazine with Codeine Oral Solution need to be made use of with caution in sufferers with impairment of hepatic purpose, and sufferers need to be monitored closely for respiratory depression, sedation, and hypotension.
Codeine: Dosage of codeine Really should not be Enhanced if cough fails to reply; an unresponsive cough must be reevaluated in five days or sooner for probable underlying pathology, which include foreign human body or reduce respiratory tract illness.
Promethazine with Codeine Oral Remedy needs to be employed with caution in individuals with bone-marrow depression. Leukopenia and agranulocytosis have been reported, normally when promethazine has actually been Utilized in association with other recognized marrow-toxic brokers.
In the event your indicators or health problems will not improve or should they grow to be even worse, contact your health practitioner. Don't share your prescription drugs with Other individuals and don't take any individual else's medication. This medication will come with an extra individual point sheet referred to as a Medication Guide. Go through it with treatment. Read through it all over again each time promethazine and codeine is refilled.
Drug dependancy is really a cluster of behavioral, cognitive, and physiological phenomena that acquire right after recurring compound use and contains: a solid desire to take the drug, challenges in controlling its use, persisting in its use Inspite of dangerous outcomes, a greater priority specified to drug use than to other activities and obligations, elevated tolerance, and from time to time a physical withdrawal.
The concomitant utilization of anticholinergic medicines with Promethazine with Codeine Oral Solution may raise hazard of urinary retention and/or critical constipation, which can lead to paralytic ileus [see Warnings and Safeguards ( five.11) ]. Observe sufferers for read more signs of urinary retention or lowered gastric motility when Promethazine with Codeine Oral Answer is made use of concomitantly with anticholinergic medicines.